Creating a dynamic GRN model – Questions (2)

• Equations that describe process dynamics

  • Mass-action type rate equations?

• Rules for (combined) effects of regulatory interactions

  • Saturable? Additive? Logical?

• Numerical representation of component values

  • Continuous? Discrete multivalued? Boolean (if so: what do 0 and 1 represent)?

• Representation of time

  • Continuous? Discrete?

• Evaluation method

  • Numerical integration of rate equations (if so: stochastic or deterministic)? Finite state automaton? Boolean switching?

Notes: